I have worked with web.py before, but I have never really used it to create anything useful, lately though, I have been working on some small projects like the ones you can find under projects.
web.py is so nice and simple, so instead of implementing my small side-projects inside django, I can just make them completely independent.
It is really simple to setup and start using, and when you're done it's easy as pie to get working with a fastcgi parser and nginx too.
There is a neat little guide here for that: Webpy + Nginx with FastCGI
Now, to manage my projects (start/stop, and deploy new ones) I have just today created a small bash script to make this easier for me, which looks as follows:
In all my projects I use main.py as the "main file", so I don't need to define this, I just put in the projects folder, and the port it should run on, and then I can control the projects, start/restart and stop them, easily.